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Proteomics Scientist

Company: Novozymes
Location: Davis
Posted on: January 16, 2022

Job Description:

Do you want to rethink your impact, and are you passionate about working with microorganisms? Then you might be our new Proteomics Scientist in Microbe Analytics & Automation.

What if you could work for a cause, not just a company?
Novozymes is the global market leader in biological solutions. We help build better lives. Together with our customers, partners and the global community, we use our innovative thinking and passion for science to boost industries and make everyday products more sustainable for the good of the planet. As the world's leading provider of industrial enzymes and microorganisms, our bio-innovation enables higher agricultural yields, low-temperature washing, energy-efficient production, renewable fuel and many, many other biological solutions that the world can benefit from today and in the future. We call it Rethink Tomorrow .

Join us as our new Proteomics Scientist, Microbe Analytics & Automation
Do you have a passion for microbes and want to help leverage Nature to develop microbial solutions for a more sustainable world? Do you have experience using proteomics to investigate challenging but important biological questions? If so, you could be our next colleague in Microbe Research. As a Proteomics Scientist, you will work on a cross-disciplinary team of experts in genomics, bioinformatics, analytical chemistry, data science, and biochemistry. -You will draw on expertise in mass spectrometry to develop and implement bottom-up proteomics methods for evaluating the performance and phenotype of wild-type and genetically modified microbes as well as to identify and characterize heterologously expressed proteins.

Welcome to Microbe Research, California
In Microbe Research, California we use classical industrial microbes and develop new ones to bring Biological Solutions to some of our customers' toughest problems in biofuels, agriculture, food & beverage, and beyond. -We are connected to other global Microbe Research sites in Berlin, Research Triangle Park, NC, and Copenhagen. -This position will join the Microbe Analytics & Automation team, where we deploy technologies for building, testing & understanding the performance and health of our microbes and protein expression strains at high, medium, and low throughputs.

In this role you'll make an impact by:
Developing, validating, implementing, and executing bottom-up proteomics methods that let us identify promising new microbes with desirable phenotypes, and characterizing lead microbes in additional detail
Applying proteomics to estimate heterologous protein expression levels in bacteria, yeast, and filamentous fungal hosts.
Using and writing software methods and custom scripts for automated capture, processing, and analysis of proteomics data
Working with a team of lab automation engineers to implement methods into high throughput formats
Working within an agile team to design and conduct scientific experiments to support multiple research projects
Actively collaborating with other Novozymes proteomics and metabolomics experts at other global sites
Interpreting experimental results and sharing them with the local and global Novozymes community
Ensuring timely delivery of results to internal or external customers
Mentoring research associates working on proteomic and metabolomic efforts.

To succeed in this position, you must have:
Demonstrated examples of bottom-up proteomics workflows you have developed and utilized for screening complex samples. -Work in microbial or non-human contexts is advantageous but not required.
Knowledge of MS-based quantification and identification methods for proteomics
Hand-on experience operating and maintaining mass spectrometry instruments
Excellent communication skills-you can succinctly explain complicated mass spectrometry methods to both novices and experts
Hands-on experience developing sample preparation methods from cultures, plants, or animal tissues (e.g. lysis & extraction methods, SPE, etc).
Demonstrated proficiency developing scripts (Python, R, JMP or other) and processes for data capture, processing, and analysis of proteomics datasets
Experience with MS-based data processing tools for proteomics (any of Genedata, Peaks, Skyline, Spectronaut, MSFragger, or MaxQuant or others)
A detail-oriented and self-driven attitude to conduct hands-on experiments in the laboratory
A PhD degree in a biological science, biochemistry, or analytical chemistry and 0-3 years post-graduate experience in a postdoc or industry. -MS or BS degrees with applicable practical experience will also be considered. -Position will be hired at level commensurate with experience.

Candidates with the following experience are especially desirable:
Previous use of Bruker TIMSTOF hardware in DDA, DIA or PRM modes as well as software for processing TIMSTOF data will be strongly favored.
Experience with visualization and interpretation of proteomics and multi-omics results
Experience in glycoproteins and post-translational modification analysis
General understanding of strain engineering techniques in bacteria, yeast, and filamentous fungi
Previous experience applying proteomics to characterize food ingredients or alternative protein applications
Additional expertise applying additional mass spectrometry methods for targeted or untargeted metabolomics
Application of proteomics and metabolomics for studying microbes, microbiomes, and host-microbe interactions in plant, animal, and human contexts.

Keywords: Novozymes, Davis , Proteomics Scientist, Other , Davis, California

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